Enhance.MD is a U.S.-based telehealth platform offering compounded GLP-1 weight loss medications and NAD+ therapy with a model built around medical rigor: required lab work, one-on-one video consultations with licensed providers, and named pharmacy partners disclosed in its terms of service. The platform is LegitScript certified and scored 94 out of 100 on Safety and Legitimacy in an independent review roundup, with a perfect 100 on Patient Reviews . However, the service is not the cheapest option on the market, does not accept HSA/FSA payments, and serves only 40 states.
Review Summary Box
| Feature | Details |
|---|---|
| Overall Rating | 4.0 / 5 ⭐ |
| Best For | Patients who want medically rigorous care with required labs, coaching, and named pharmacy partners |
| Product Type | Telehealth Platform (GLP-1 Weight Management + NAD+ Therapy) |
| GLP-1 Medications | Compounded semaglutide, compounded tirzepatide, and a semaglutide-tirzepatide blend |
| NAD+ Delivery | Subcutaneous injection and sublingual wafer |
| GLP-1 Pricing | $212–$379/month (flat at every dose) |
| NAD+ Pricing | Injections from $169/month; sublingual wafers from $84/month (prepaid) |
| LegitScript Certified | Yes |
| States Served | 40 states + DC |
| Pharmacy Partners | Rite-Away Pharmacy, Vios Compounding Pharmacy, TruMedsRx |
| Lab Work | Required before prescribing; repeated every 6 months |
| Insurance | Not accepted (no HSA/FSA) |
What Is Enhance.MD?
Enhance.MD is a telehealth clinic that sells compounded semaglutide, compounded tirzepatide, a blend of the two, and NAD+ therapy. The prescribers are employed by two affiliated medical practices: Enhance Wellness PC and iThriveMD PC . The platform is LegitScript certified, an independent verification service that investigates websites to promote security and transparency .
The most useful structural feature of the platform is its pricing transparency. Enhance.MD prints the ongoing price next to the intro price on every plan card, so you see what you pay in month two before you commit . A “Medication & Pricing” tab sits at the top of the site .
What Makes It Different
Required lab work before prescribing. Unlike platforms that prescribe without any baseline screening, Enhance.MD requires metabolic blood work before writing a prescription. The labs are included at no extra cost and are repeated every six months . This is a higher medical standard than async-only platforms.
One-on-one video consultations. Every appointment is a video visit with a board-certified provider. First-time visits are 20 minutes; reevaluations are 15 minutes; monthly follow-ups are 10 minutes. Patients pick their own provider from a list and see live availability .
Named pharmacy partners. The terms of service name Rite-Away Pharmacy, Vios Compounding Pharmacy, and TruMedsRx — three named partners in a public document, which most competitors never do .
All-inclusive pricing. No membership fee, no consultation fee, no lab fee. One monthly price covers medication, provider visits, labs, syringes, alcohol pads, and one-on-one nutrition and fitness coaching .
How Does Enhance.MD Work?
The process follows a structured clinical pathway.
The Intake Process
- Complete the online health questionnaire — The intake seems short at first, but a second round of questions begins after you enter payment information .
- Upload a photo of your driver’s license or passport and a clear photo of your face for identity verification .
- Complete required lab work at a Quest Diagnostics facility, or agree to submit results before month two .
- Schedule a video consultation — First-time visits are 20 minutes. The tester scheduled two days out from finishing intake .
- Receive your prescription — Written within 24 hours of the visit .
- Medication ships overnight via FedEx Standard Overnight. Tracking comes through FedEx directly, not through Enhance.MD .
- Submit lab work before month two — Labs are required and repeated every six months .
The NAD+ Process
The NAD+ program follows a similar structure but with a higher degree of medical personalization. According to an independent review, Enhance.MD assigns each patient to a specific licensed physician who conducts a dedicated one-on-one consultation before building a protocol — not an algorithmic intake . Ongoing medical support is included, so the physician monitors response and proactively recommends dose adjustments .
GLP-1 Pricing Breakdown
Plan Comparison
| Plan | Medication | First Month | Ongoing Monthly |
|---|---|---|---|
| GLP-1 Core | Compounded semaglutide | $112 | $212 |
| GLP-1 Advanced | Compounded tirzepatide | $180 | $280 |
| GLP-1 Elite | Semaglutide + tirzepatide blend | $222 | $322 |
Tirzepatide Plan Details
| Plan Duration | First Month | Ongoing Monthly | Billing Cycle |
|---|---|---|---|
| 1 month | $279 | $329 | Every 4 weeks |
| 3 months | $213 | $313 | Every 12 weeks |
| 6 months | $196 | $296 | Every 24 weeks |
| 12 months | $180 | $280 | Every 48 weeks |
A year on the one-month plan costs approximately $3,898**. The 12-month plan drops that to approximately **$3,260, paid upfront .
The Key Pricing Feature
The most important pricing detail: the price does not go up as the dose increases. The product page states “Same Pricing, All Doses” . When a patient escalates from a starter dose to the maximum dose, the monthly bill stays the same. This is a meaningful advantage over platforms that charge more at higher doses.
NAD+ Pricing Breakdown
| Format | Starting Price | Notes |
|---|---|---|
| Sublingual Wafer | From $84/month | Prepaid commitment |
| Subcutaneous Injection | From $169/month | Prepaid commitment |
What’s Included
- One-on-one physician consultation
- Custom dosing protocol built around your health profile
- Ongoing medical support (not just a one-time consult)
- Provider check-ins, supplies, messaging, and lab tracking .
User Reviews and Feedback
Positive Experiences
“I feel this company is 100% awesome.”
“I always have access to a consult with nurse practitioner, within 24 hours. I always feel the NP is counseling me in a way that is for my benefit.” — ConsumerAffairs reviewer
“I’ve lost 45 lbs since Jan 25.”
“I’m happy I chose EnhanceMD.” — ConsumerAffairs reviewer
Patient Reviews Score: 100/100
An independent review roundup gave Enhance.MD a perfect 100 on Patient Reviews, the only clinic on the roundup to do that .
Trustpilot Rating: 4.1/5
Enhance.MD holds a 4.1 out of 5 rating on Trustpilot from 74 reviews .
Common Complaints
“No drug info or injection instructions in the box”
The first-hand tester noted that the medication shipped without drug information or injection instructions included in the packaging .
“In-portal cancel button requires a phone call”
Cancellation is not available through the online portal and requires calling support .
“Driver’s license and face photo required for verification”
Identity verification requires uploading a government photo ID and a selfie, which some users may find cumbersome .
“Expensive for compounded semaglutide”
At $249/month (or $212 on annual prepay) for semaglutide, Enhance.MD is more expensive than IVY RX ($175/mo) or Hims ($199/mo) if you do not value the included labs and coaching .
“No HSA/FSA accepted”
The platform does not accept HSA or FSA cards, unlike some competitors .
“Only 40 states”
Ten states are excluded: Alabama, Arkansas, Georgia, Hawaii, Louisiana, Missouri, Mississippi, South Carolina, Tennessee, and West Virginia . Most major competitors serve all 50.
“Not BBB Accredited”
Enhance.MD is not accredited by the Better Business Bureau, and the Trustpilot sample size is smaller than Hims or Ro .
“Customer support hours limited”
Phone support is available Monday through Friday, 9 AM to 6 PM EST only, with no weekend support .
Safety and Regulatory Considerations
Compounded GLP-1 Products Are Not FDA-Approved
No compounded GLP-1 medication is FDA-approved. The FDA does not review compounded preparations before marketing for safety, effectiveness, or quality. A compounded product is not necessarily a generic or an equivalent to an approved brand. Evidence and outcome data for approved Ozempic or Mounjaro cannot establish the performance of a compounded product .
NAD+ Evidence Base
Most research on NAD+ benefits focuses on oral precursors like NMN and NR, not injectable NAD+ directly. Large human clinical trials proving the benefits of injectable NAD+ are still lacking . If you are considering this product, manage your expectations — you might feel benefits, or you might not notice anything .
Required Lab Work as a Safety Feature
Enhance.MD requires metabolic blood work before prescribing and repeats labs every six months . For patients with underlying conditions, this screening matters. It is a higher medical standard than platforms that prescribe without labs.
Who Should Exercise Caution
- Patients in the 10 excluded states — the service is not available in AL, AR, GA, HI, LA, MS, MO, SC, TN, or WV
- Anyone who needs HSA/FSA payment — the platform does not accept these cards
- Patients who need weekend support — phone support is weekdays only
- Anyone who wants only FDA-approved finished products — compounded GLP-1 products are not FDA-approved
- Patients expecting dramatic NAD+ anti-aging results — the evidence base is preliminary
Who Should Consider Enhance.MD
Enhance.MD is best for patients who want medically rigorous care with required labs, one-on-one video consultations, named pharmacy partners, and included coaching. The all-inclusive pricing model means no surprise charges for labs or consultations, and the flat pricing at every dose is a genuine advantage for patients who will titrate upward.
Who Should Look Elsewhere
You should consider a different provider if you want the cheapest possible compounded semaglutide (IVY RX and Hims are cheaper), need HSA/FSA payment (Enhance.MD does not accept it), live in one of the 10 excluded states, or need weekend customer support.
Final Verdict
Strengths
- ✅ LegitScript certified — independent third-party verification
- ✅ Named pharmacy partners in terms of service — Rite-Away, Vios, TruMedsRx
- ✅ Required lab work before prescribing, repeated every 6 months
- ✅ One-on-one video consultations with board-certified providers
- ✅ Flat pricing at every dose — “Same Pricing, All Doses”
- ✅ All-inclusive pricing — no separate lab, consultation, or membership fees
- ✅ Nutrition and fitness coaching included
- ✅ NAD+ therapy available in both injection and sublingual formats
- ✅ Scored 94/100 on Safety and Legitimacy and 100/100 on Patient Reviews in independent roundup
Weaknesses
- ⚠️ Only 40 states served — 10 states excluded
- ⚠️ No HSA/FSA accepted
- ⚠️ More expensive than some competitors — $249/mo for semaglutide vs. $175–$199 at IVY RX and Hims
- ⚠️ No drug info or injection instructions in the box
- ⚠️ In-portal cancel button requires a phone call
- ⚠️ Weekday-only phone support
- ⚠️ Not BBB accredited
- ⚠️ Limited independent NAD+ reviews — platform is relatively new in the NAD+ space
Who May Benefit
Patients who value medical rigor, transparent pricing, and included coaching will find Enhance.MD a well-structured option. Those who understand that compounded GLP-1 products are not FDA-approved and accept that risk — and who live in one of the 40 served states — are best positioned to use the platform.
Who Should Avoid
- Patients in the 10 excluded states
- Anyone who needs HSA/FSA payment
- Patients who prioritize the lowest possible price over included labs and coaching
- Anyone who needs weekend customer support
- Patients who want only FDA-approved finished products
Overall Recommendation
Rating: 4.0 out of 5 Stars
Enhance.MD offers a medically rigorous, transparently priced telehealth platform for compounded GLP-1 weight management and NAD+ therapy. The required lab work, one-on-one video consultations, named pharmacy partners, and LegitScript certification set it apart from less rigorous competitors. The flat pricing at every dose and all-inclusive model mean predictable costs. However, the service is more expensive than some alternatives, does not accept HSA/FSA, serves only 40 states, and lacks weekend support. For patients who value medical oversight and included coaching, Enhance.MD is a strong option worth considering.
Frequently Asked Questions
Is Enhance.MD legit?
Yes. Enhance.MD is LegitScript certified, names its pharmacy partners in its terms of service, requires lab work before prescribing, and employs board-certified providers through its affiliated medical practices, Enhance Wellness PC and iThriveMD PC .
How much does Enhance.MD cost?
GLP-1 Core (semaglutide) starts at $112 for the first month and $212 ongoing. GLP-1 Advanced (tirzepatide) starts at $180 first month and $280 ongoing. GLP-1 Elite (blend) starts at $222 first month and $322 ongoing. NAD+ injections start at $169/month, and sublingual wafers start at $84/month .
What medications does Enhance.MD prescribe?
Compounded semaglutide, compounded tirzepatide, a semaglutide-tirzepatide blend, and NAD+ therapy. All compounded products are not FDA-approved .
Does Enhance.MD accept insurance?
No. The platform does not accept insurance, HSA, or FSA payments. Payment is by Visa, Mastercard, Discover, or American Express .
What states does Enhance.MD serve?
40 states plus Washington DC. It does not serve Alabama, Arkansas, Georgia, Hawaii, Louisiana, Missouri, Mississippi, South Carolina, Tennessee, or West Virginia .
Does Enhance.MD require lab work?
Yes. Metabolic blood work is required before prescribing and is repeated every six months. Labs are included at no extra cost .
What is the refund policy?
If you are deemed ineligible for weight loss medications after the intake process, you receive a 100% refund. You do not lose your initial payment .
Is Enhance.MD FDA approved?
No. Telehealth platforms are not FDA-approved, and compounded GLP-1 medications are not FDA-approved. The FDA does not review compounded preparations before marketing for safety, effectiveness, or quality .
Does Enhance.MD offer NAD+ therapy?
Yes. NAD+ is available as a subcutaneous injection (from $169/month) or sublingual wafer (from $84/month), with one-on-one physician consultations and custom protocols .
Where can I buy Enhance.MD?
Enhance.MD is available through its official website at enhance.md.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Compounded GLP-1 medications are not FDA-approved. Always consult a qualified healthcare professional before starting any new medication or treatment, especially if you have existing health conditions, take medications, or are pregnant or nursing. Individual results may vary.
This response is AI-generated, for reference only.
